On this page you can find a summary of the last news and researches from scientist publications sources. Most of these reasearches are pre-clinical conclusions on small groups of people or observations on animals, this article or our products are absolutely not intended to diagnose, treat, cure or prevent any disease. Consult your professional healthcare for any specific condition.

What is Cannabidiol?

The cannabis plant has gained much attention in recent years because of its medicinal effects. The cannabinoid compounds that are derived mainly from cannabis are called phytocannabinoid, of which two are the most commonly studied: 9-delta tetrahydrocannabinol (THC) and cannabidiol (CBD). THC is the most abundant cannabinoid in cannabis, and it has psychoactive properties, and thus, it makes you feel ‘high’. Unlike THC, CBD does not cause any psychoactive effects and is being widely studied for its therapeutic potential in treating many medical conditions, including pain, various inflammatory conditions, gastrointestinal diseases, and many others.

Several animal and human research studies have supported the safety and effectiveness of CBD use in humans for many medical disorders. According to a national-based research study in the United States, CBD is most commonly used for the following medical purposes: pain, anxiety, insomnia, depression, post-traumatic stress disorder, cancer-related nausea and vomiting, and migraine. Also, CBD has been approved by the Food and Drug Administration (FDA) to be used as a treatment option for patients with drug-resistant epileptic syndromes.

Can CBD be Used in Pregnant Patients?

Most pregnant women often complain of pregnancy-associated symptoms, such as nausea, vomiting, and anxiety, and CBD can help improve these symptoms. CBD is suggested to help with the following pregnancy-related health problems:

  1. Nausea
  2. Morning sickness
  3. Pain
  4. Inflammatory conditions
  5. Edema
  6. Anxiety
  7. Depression
  8. Constipation
  9. Headache and Migraine

CBD and pregnancy

That being said, here are many online resources that discuss the potential benefits of CBD in treating some symptoms or conditions during pregnancy; however, we recommend that pregnant women consult their physician first before taking CBD, particularly to adjust their CBD dose to make sure that all harms to the fetus are avoided.

As in the case with most drugs, CBD can be used with minimal to no side effects in adults; however, there are some safety concerns regarding its use in pregnant women and in children below 18 years of age. Based on a recent statement from the FDA, there is currently no comprehensive and high-quality research that explores the effects of CBD on the developing fetus, pregnant women, and breastfed infants. In an old animal study, high doses of CBD have been noted to cause disruption of the testicular function in male rats.

Overall, as per the FDA recommendations, CBD should not be used in pregnant women without consulting a physician.

What is the Influence of CBD on Pregnancy?

Marijuana has been long known as the most frequently used illicit drug by pregnant women, with a significant increase in its usage in recent years. Although cannabis, in general, has been known to be harmful to both the consumer and potentially to the offspring, recent research suggests that at least some of its individual components can provide a wide range of clinical benefits, with few to no side-effects at all. In the same context, CBD has recently gained much focus by researchers for its beneficial properties and remarkable safety profile. The clinical use of CBD, particularly for pediatric and adult patients, has been increasing in the past few years. However, very little is known about the potential effectiveness or the harmful effects of CBD when used during pregnancy, either on pregnant women or on the fetus.

Various cannabinoid compounds, including CBD, have been reported to easily cross the placenta. In fact, some studies have warned against the use of cannabinoids during pregnancy because fetal exposure to these compounds may interrupt the proper development of the immune system of the fetus. Of note, there is extremely scarce data on the effects or the potential harms of CBD use during pregnancy. Despite this, some research highlighted the important role of cannabinoids, particularly endocannabinoids, in promoting and regulating all the steps of pregnancy, starting from fertilization to implantation in the uterus and parturition.

What do Animal Studies Say?

A recent animal study investigated the effects of CBD use on gastroschisis in rat fetuses through the administration of CBD to the mother. Gastroschisis is known as a congenital malformation of the front of the abdominal wall. This condition occurs in 1/4000 live births globally, in which a small opening in the abdomen exists that connects the inside organ to the outside environment, leading to a high risk of developing herniation and further harmful complications. The current approach to prevent the occurrence of this condition is via the maternal administration of corticosteroids during pregnancy. Although corticosteroids are effects, they have undesirable adverse events that can negatively affect both the pregnant women and the fetus while increasing their risk of multiple infections.

In this research study, the degree of inflammation in rats with gastroschisis was assessed histologically. Some rats were treated with CBD, while others were treated with the usual standard care. Surprisingly, the use of CBD resulted in a marked reduction in the degree of inflammation by all measures. This finding suggests that CBD can be a promising future therapy for preventing and treating this condition. Also, no side effects were reported with the use of CBD both in pregnant rats or their offspring. This study provides significant conclusions to be drawn regarding both the effective transmission of CBD through the placenta and its effect on fetal disorders in utero. However, it should be noted that the available information regarding CBD use during pregnancy is very limited, and it may not be as safe as it is in non-pregnant women.

In preclinical studies of human umbilical veins, it was found that CBD is anti-angiogenic (prevents blood vessel formation) to the endothelial cells of the umbilical veins, which may reduce angiogenesis, and this may lead to the occurrence of serious complications, such as placental insufficiency and fetal death. Physicians are also concerned with the use of CBD during pregnancy because it may dysregulate the immune function of the developing fetus by altering cytokine levels, which may increase the fetuses’ risk of developing cancer and infections later in life.

A Take-Home Note

Although CBD has been shown effective in treating pain, inflammation, anxiety, depression, constipation, headache, and many other medical problems, its effectiveness and safety in pregnant women have not been thoroughly investigated. Some animal studies highlight the easy transmission of CBD through the placenta, as well as its effectiveness in treating certain fetal conditions. However, there are some concerns regarding its safety for both the developing fetus and the mother. Therefore, it is recommended not to use CBD during any trimester in pregnancy without consulting a physician first. Also, pregnant women should use other alternatives that are well-known for their safety on the developing fetus for treating their complaints or medical problems instead of using a drug that is not confirmed to be safe.

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